Arsk (Russian: Арск, IPA:; Tatar: Арча) is a town and the administrative center of Arsky District in Tatarstan, Russia, located on the Kazanka River, 65 kilometers (40 mi) from the republic's capital of Kazan.

2024年12月24日 · ARSK (Arylsulfatase Family Member K) is a Protein Coding gene. Diseases associated with ARSK include Mucopolysaccharidosis, Type X and Mucopolysaccharidosis-Plus Syndrome. Among its related pathways are Sphingolipid metabolism and Metabolism of proteins.

Arsky District (Russian: А́рский райо́н; Tatar: Арча районы) – is a territorial administrative unit and municipal district of the Republic of Tatarstan within the Russian Federation. The district is located in the northern part of the republic. The administrative center is the city of Arsk. [3]

Background: Human sulfatases play key roles in physiology and cause numerous pathological conditions upon deficiency/misregulation. Results: ARSK is ubiquitously expressed, localizes to lysosomes, and shows arylsulfatase activity at acidic pH. ...

2025年1月4日 · Arylsulfatase K, a novel lysosomal sulfatase. The identification, molecular cloning and initial characterization of three new members of this human gene family is reported. Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids.

Arylsulfatase K (ARSK) is a recently characterised lysosomal hydrolase involved in GAG degradation that removes the 2-O-sulfate group from 2-sulfoglucuronate. Knockout of Arsk in mice was consistent with mild storage pathology, but no human phenotype has yet been described.

Recently, we identified and characterized the lysosomal enzyme arylsulfatase K (Arsk) exhibiting glucuronate-2-sulfatase activity as needed for the degradation of heparan sulfate (HS), chondroitin sulfate (CS) and dermatan sulfate (DS).

2023年11月23日 · Clinical resource with information about ARSK, Mucopolysaccharidosis, type 10, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2013年10月18日 · A novel member of this family, arylsulfatase K (ARSK), was identified bioinformatically through its conserved sulfatase signature sequence directing posttranslational generation of the catalytic formylglycine residue in sulfatases.

2024年6月17日 · Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]). [supplied by OMIM, Mar 2008]