2024年12月24日 · ARPC4 (Actin Related Protein 2/3 Complex Subunit 4) is a Protein Coding gene. Diseases associated with ARPC4 include Developmental Delay, Language Impairment, And Ocular Abnormalities and Microcephaly. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and G-protein signaling RAC1 in cellular process.

Actin-related protein 2/3 complex subunit 4 is a protein that in humans is encoded by the ARPC4 gene. [5] [6] [7]

2025年2月9日 · ARPC4 promotes bladder cancer cell invasion and is associated with lymph node metastasis. Expression of the ARPC4 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages

肌动蛋白相关蛋白 2/3 复合亚基 4： 该基因编码人类 Arp2/3 蛋白复合物的七个亚基之一。该复合物控制细胞中的肌动蛋白聚合，并在整个真核生物进化过程中得到保护。该基因编码 p20 亚基，这是肌动蛋白成核和与 F-肌动蛋白高亲和力结合所必需的。可变剪接导致多个转录本变体。该基因与 …

The expression of ARPC4 protein in H37Rv cells was confirmed by checking the synthesis of ARPC4 gene transcript. For this, total RNA was extracted from exponentially growing cultures of Mtb H37Rv (control) and H37Rv harbouring the ARPC4pVV16 plasmid (H37Rv/ARPC4) and reverse transcribed to obtain cDNA (as per the methods described below).

2024年9月19日 · Expression of the ARPC4 subunit of human Arp2/3 severely affects mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages. Ghosh A, Tousif S, Bhattacharya D, Samuchiwal SK, Bhalla K, Tharad M, Kumar S, Prakash P, Kumar P, Das G, Ranganathan AGhosh A, et al .

ARPC4 is a core subunit of the actin-related protein (ARP2/3) complex, which catalyzes the formation of F-actin networks. We show that the recurrent ARPC4 missense change is associated with a decreased amount of F-actin in cells from two affected individuals.

Description: Homo sapiens actin related protein 2/3 complex subunit 4 (ARPC4), transcript variant 1, mRNA. (from RefSeq NM_005718) RefSeq Summary (NM_005718): This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution.

Predicted to be located in several cellular components, including actin cytoskeleton; cell projection; and nucleus. Predicted to be part of Arp2/3 protein complex. Is expressed in dorsal root ganglion. Used to study psoriasis. Orthologous to several human genes including ARPC4-TTLL3 (ARPC4-TTLL3 readthrough).

ARPC4的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为该基??因编码的7个亚基的人类的Arp2 / 3蛋白质复合物中的一个。 这种复杂的控制肌动蛋白聚合在细胞和真核细胞在整个进化中得到了保存。