2024年12月24日 · AP2A1 (Adaptor Related Protein Complex 2 Subunit Alpha 1) is a Protein Coding gene. Diseases associated with AP2A1 include Neural Tube Defects and Hypocalciuric Hypercalcemia, Familial, Type Iii.

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma).

2025年2月20日 · The AP2A1 protein might not be the fountain of youth we dream of—no magic smoothie or herb has claimed it yet. But its role in endocytosis and disease keeps it on our radar. Could it be a key to longevity?

We identified, together with our previous proteomic study, that AP2A1 (alpha 1 adaptin subunit of the adaptor protein 2) is upregulated in senescent cells along the length of enlarged stress fibers.

2025年2月18日 · "Suppressing AP2A1 in older cells reversed senescence [aging] and promoted cellular rejuvenation, while AP2A1 overexpression in young cells advanced senescence," he added.

2025年2月24日 · By targeting AP2A1—a potential “master switch” in cellular aging—researchers may unlock new strategies to slow, halt, or even reverse the aging process. While this combination is hypothetical, it is grounded in well-established mechanisms of action and leverages drugs with proven safety profiles.

2025年2月19日 · Summary: Scientists have identified a key protein, AP2A1, that may hold the secret to reversing cellular aging. The study found that suppressing AP2A1 in older cells led to rejuvenation, while overexpressing it in young cells accelerated senescence.