This analysis revealed a high prevalence of terbinafine resistance, predominantly linked to specific SQLE substitutions, particularly Phe397Leu, highlighting the need for ongoing surveillance and tailored antifungal strategies for managing these infections.

Antifungal Resistance. Candida biofilms present a formidable challenge due to their resistance to antifungal treatments. This resistance involves genetic and biochemical strategies that fortify the biofilm against external threats. One primary mechanism is the upregulation of efflux pumps, which expel antifungal compounds, reducing ...

Purpose of Review Cholangiocarcinoma (CCA) is the most lethal and common malignant tumours that occur in the bile ducts. Although it is relatively rare, it is prevalent with an annual incidence rate of 0.3–6% per 100,000 people globally. The onset of CCA can be influenced by several risk factors, including exposure to invasive fungal pathogens. Immunocompromised patients with CCA that ...

Recent research has yielded promising novel antifungal agents that target unique pathways in fungal cells, minimizing the likelihood of resistance development. For instance, fosmanogepix, a first-in-class agent, targets the Gwt1 enzyme involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis, an essential process for fungal cell wall ...

Finally, the major issue of antifungal resistance, mainly for dermatophytic infections, was reviewed in the context of the formation of relevant biofilms by Contribution 12.