ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism of polyunsaturated fatty acids to a wide range of physiologically and pathologically important products. Gene Function

花生四烯酸 15-脂氧合酶： 该基因编码脂氧合酶蛋白质家族的成员。编码的酶作用于各种多不饱和脂肪酸底物，产生各种具有生物活性的脂质介质，如类花生酸、hepoxilins、脂氧素和其他分子。编码的酶及其反应产物已被证明可以调节炎症和免疫力。已在人类基因组中鉴定出该基因的多个假基 …

2024年12月24日 · ALOX15 (Arachidonate 15-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX15 include Asthma and Colorectal Cancer. Among its related pathways are Biosynthesis of DPA-derived SPMs and Fatty acid metabolism.

Recently, it has been suggested that various LOX isoforms should be named according to their encoding genes, such as all 12/15-LOX orthologs from different species should be called as ALOX15. The purpose of this review is to refresh our understanding on the role of 12/15-LOX (ALOX15) in the pathogenesis of various diseases. Table 1.

Arachidonic acid 15-lipoxygenase (ALOX15) is an enzyme that can oxidize polyunsaturated fatty acids. ALOX15 is strongly expressed in airway epithelial cells, where it catalyzes the conversion of arachidonic acid to 15-hydroxyeicosatetraenoic acid (15-HETE) involved in various airway inflammatory dis …

花生四烯酸 15-脂肪氧化酶 (alox15) 是一种可以氧化多不饱和脂肪酸的酶。alox15 在气道上皮细胞中强烈表达，在那里它催化花生四烯酸转化为 15-羟基二十碳四烯酸 (15-hete)，参与各种气道炎症疾病。

12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The …

2025年2月8日 · ALOX15 orthologs, commonly known as 12/15-lipoxygenases, were suggested to exhibit mainly arachidonic acid 12-lipoxygenating specificity in mammals ranked in evolution lower than gibbons and 15-lipoxygenating specificity in the higher ranking primates [Review].

2015年7月26日 · 在接下来的几十年中，alox15 得到了广泛的表征，并在许多细胞体外系统以及各种整体动物疾病模型中研究了其生物学功能。 本综述旨在总结目前关于 ALOX15 在不同物种（人、小鼠、兔、大鼠）中的蛋白质化学、分子生物学和酶学特性的知识，及其在细胞生理学和 ...

花生四烯酸脂氧合酶-15(Arachidonate 15-lipoxygenase,ALOX15)是铁死亡的重要调控因子,它可以催化多不饱和脂肪酸(Polyunsaturated fatty acid,PUFA)生成脂质氢过氧化物,从而促进铁死亡的发生。