Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene. [5] [6] [7] The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family.

2023年7月14日 · 摘要长链酰基辅酶 a (coa) 合酶 4 (acsl4) 是一种将 coa 酯化为特定多不饱和脂肪酸（如花生四烯酸和肾上腺酸）的酶。根据积累的证据，acsl4 催化的花生四烯酰辅酶 a 生物合成通过触发磷脂过氧化而有助于铁死亡的执行。

2024年12月24日 · ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) is a Protein Coding gene. Diseases associated with ACSL4 include Intellectual Developmental Disorder, X-Linked 63 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Fatty acid metabolism and Integration of energy metabolism.

该研究发现，as-252424是一种特异性和靶向性的acsl4抑制剂，具有显著的抗铁死亡功能，并揭示了其在调控铁死亡中的潜在作用和分子机制，为铁死亡相关疾病的治疗提供了一种潜在治疗方法。

2024年12月10日 · ACSL4. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. 铁死亡是一种由谷胱甘肽过氧化物酶4（GPX4）调控的细胞坏死形式。早期研究揭示了erastin (ERA)通过抑制系统xc-来诱导铁死亡，随后GPX4抑制剂RSL3也被发现。然而，某些细胞类型对铁死亡具有抗性。

ACSL4 is an enzyme involved in the intracellular conversion of long-chain fatty acids and coenzyme A into fatty-acid coenzymes. It plays a vital role in various biological processes, including maintaining cell membrane structure, energy metabolism, ...

2024年12月13日 · acsl4缺失抑制了sk-hep-1-luc细胞的肺转移，但未显著改变体外增殖或皮下肿瘤生长，表明acsl4在肝癌中的促外渗作用具有普遍性。 此外，用ARA处理SK-HEP-1细胞显著增强了小鼠肺部的转移信号，类似趋势也在4T1乳腺癌小鼠模型中得到验证。

关于 acsl4 Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:109,641,335-109,733,257 (from NCBI) This gene has 18 transcripts (splice variants), 271 orthologues, 12 paralogues and is associated with 4 phenotypes.

2022年7月13日 · Recently, acyl-CoA synthetase long-chain family 4 (ACSL4) is found be participated in the activation of long chain fatty acids metabolism, immune signaling transduction, and ferroptosis, which can be a promising potential target and biomarker for anticancer.

ACSL4 is not only a sensitive monitor of ferroptosis, but also an important contributor of ferroptosis. ACLS4 and ACLS3 have roles in insulin secretion; Silencing of ACSL4 eliminated the 17beta-estradiol-induced increase in AA and EPA uptake. ACSL4 plays a tumor-suppressive role in gastric cancer.