Aflatoxin B 1 is considered the most toxic aflatoxin and it is highly implicated in hepatocellular carcinoma (HCC) in humans. [9] . In animals, aflatoxin B 1 has also been shown to be mutagenic, [10] teratogenic, [11] and to cause immunosuppression. [12] .

The suspect human hepatocarcinogen aflatoxin B1 (AFB1) is a well-known potent initiator of hepatic tumors in rainbow trout (Oncorhynchus mykiss). Both hepatocellular carcinomas and mixed hepatocellular/cholangiocellular carcinomas are induced by AFB1 in trout, with the mixed form predominating.

2023年2月19日 · AFB1 is believed to be the most potent among all aflatoxins. Aflatoxin M1 (AFM1) is found in the fermentation broth of A. parasiticus, but it and aflatoxin M2 are also developed when an infected liver metabolizes AFB1 and AFB2. AFM1 can be transmitted by milk.

In the case of aflatoxin B1 (AFB1), the best studied aflatoxin, AFB1-exo 8,9-epoxide, which is formed as the first step of AFB1 metabolism by microsomal cytochrome enzyme (CYP450) has been considered as the ultimate responsible for genotoxicity.

Aflatoxin B1 (AFB1) is a fungal metabolite found in animal feeds and human foods. It is one of the most toxic and carcinogenic of aflatoxins and is classified as a Group 1 carcinogen. Dietary exposure to AFB1 and infection with chronic Hepatitis B Virus (HBV) make up two of the major risk factors for hepatocellular carcinoma (HCC).

AFB1 is a lipid-soluble agent that is synthesized optimally at 25 °C and is a derivative of difuranoxano-naphtho-ketone consisting of a difuran ring and a coumarin ring, is carcinogenic, and there are over 20 AFB described to this day, e.g., B2, B2a, G1, G2a, and M2.

This review focuses on the metabolism of AFB1, including epoxidation and DNA adduction, as it concerns the initiation of cancer and the underlying mechanisms. The link between AFB1 consumption and HCC is also discussed including synergistic …

2019年2月1日 · Aflatoxin B1 (AFB1) is the most potent of these compounds and has been well-characterized to lead to the development of hepatocellular carcinoma (HCC) in humans and animals. This review focuses on the metabolism of AFB1, including epoxidation and DNA adduction, as it concerns the initiation of cancer and the underlying mechanisms.

AFB1 is the most carcinogenic of AF. AFB1 contamination of agricultural commodities poses a considerable risk to human and livestock health and high economic losses occur in the country crops and animals.

2024年11月11日 · Aflatoxin B1 (AFB1) is a mycotoxin that widely found in the environment and mouldy foods. AFB1 initially targets the intestine, and AFB1-induced intestinal injury cannot be ignored. Lactobacillus amylovorus (LA), a predominant species of Lactobacillus, plays a role in carbohydrate metabolism.