A 83-01 is a potent inhibitor of activin receptor-like kinase (ALK) including ALK5 (type I transforming growth factor-β receptor), ALK4 (type IB activin receptor), and ALK7 (type I NODAL receptor) with IC₅₀ = 12, 45, and 7.5 nM, respectively (Tojo et al.).

a 83-01 是一种有效的 tgf-β i 型受体 alk5，alk4 和 alk7 的抑制剂，能够抑制 alk5，alk4 和 alk7 诱导的转录，ic50 值分别为 12 nm，45 nm 和 7.5 nm。- 高纯度，全球文献引用。

A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor ALK4 and type I nodal receptor ALK7, with IC50s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4 and ALK7, respectively.

A 83-01 is a potent and selective inhibitor of TGF-β type I receptor ALK5 kinase, activin type IB receptor ALK4, and nodal type I receptor ALK7 with an IC 50 value of 12, 45, and 7.5 nM, respectively (1).

A 83-01 is a TGFβ kinase/activin receptor-like kinase (ALK 5) inhibitor (IC 50 =12 nM) that prevents phosphorylation of Smad2/3 and inhibits growth induced by TGFβ. A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition.

StemMACS™ A83-01 is a potent inhibitor of the TGF-beta, Activin and Nodal signaling pathway. A83-01 inhibits the activin receptor like kinases ALK4, ALK5, and ALK7 thereby preventing the phorphorylation of their downstream targets SMAD2 and SMAD3.

This study proposes using A83-01 to inhibit mast cell differentiation for mouse HSPC cultured in the presence of IL-3. A83-01 blocked the phosphorylation of Smad2 and led to a 20,000-fold expansion of lin-ckit+ cells and a 3800-fold expansion of LSK cells.