5-Iodo-2-aminoindane (5-IAI) is an entactogen drug of the 2-aminoindane group. [2] . Human anecdotal reports suggest that it is entactogenic but produces little euphoria or stimulation. [2] The drug acts as a releasing agent of serotonin, norepinephrine, and dopamine. [2][3] It produces much less serotonergic neurotoxicity than MDMA in animals. [2]

2013年3月27日 · In 2011, this compound, a psychoactive derivative of 2-aminoindane, was identified in recreational products sold in the United Kingdom. 5-IAI is a rigid analogue of p-iodoamphetamine producing MDMA-like effects. The aim of this paper is to summarize the clinical, pharmacological, and toxicological information about this new potential drug of abuse.

2010年8月13日 · 5-IAI (5-Iodo-2-aminoindane) is a rigid analogue of amphetamine that has been demonstrated to behaviorally substitute for MDMA, and acts as a monoamine releasing agent. The compound has been suggested to present similar serotonergic neurotoxicity, though considerably lower in severity, to MDMA.

5-Iodo-2-aminoindan | C9H10IN | CID 131506 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

5-Iodo-2-aminoindane (5-IAI) is an entactogen drug of the 2-aminoindane group. Human anecdotal reports suggest that it is entactogenic but produces little euphoria or stimulation. Quick Facts Clinical data, Other names ... The drug acts as a releasing agent of serotonin, norepinephrine, and dopamine.

ABSTRACT: The synthesis, analysis, and characterization of 4- and 5-iodo-2-aminoindan (commonly referred to as “4-IAI” and “5-IAI”) are discussed. Analytical data (mass spectrometry, nuclear magnetic resonance spectroscopy, and infrared …

In the acidic gold chloride reagent, 5-IAI forms distinct long blades with serrated edges. The blades are generally branched with one long blade and shorter branches. The blades appear blue to light purple to white under cross polars.

5-IAI is a psychoactive analog of p-iodoamphetamine and is indistinguishable, in its physiological effects, from 3,4-methylenedioxymethamphetamine in rats. 1 A single 40 mg/kg dose of 5-IAI significantly reduces both serotonin uptake sites and hippocampal serotonin levels in rats. 2 This product is intended for forensic applications.

A rigid analogue, 5-iodo-2-aminoindan (5-IAI), of the serotonin neurotoxic halogenated amphetamine p-iodoamphetamine (PIA) was pharmacologically evaluated for production of serotonin neurotoxicity.

Aliases: 5iai. A monoamine triple releaser first synthesised by David Nichols, possesses similar properties to MDMA. Probably neurotoxic in humans, however the extent of this is unclear.