The 26S proteasome is the major protease in eukaryotic cells, responsible for protein degradation in both the cytosol and the nucleus. Ubiquitin modifications target condemned proteins to the proteasome.

2018年6月20日 · As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic machine responsible for regulated protein degradation in eukaryotic cells.

2016年7月22日 · The 26S proteasome is a large, ∼ 2.5 MDa, multi-catalytic ATP-dependent protease complex that serves as the degrading arm of the ubiquitin system, which is the major pathway for regulated...

2024年10月3日 · The 26S proteasome is involved in degrading and regulating the majority of proteins in eukaryotic cells, which requires a sophisticated balance of specificity and promiscuity. In this Review, we...

The 26S proteasome is a large multi-protein complex involved in the regulated degradation of ubiquitinated proteins in the cell. The 26S proteasome has been shown to control an increasing number of essential biochemical mechanisms of the cellular lifecycle including DNA synthesis, repair, transcription, translation and cell signal transduction.

The 26S proteasome is the essential compartmental protease in eukaryotic cells required for the ubiquitin-dependent clearance of damaged polypeptides and obsolete regulatory proteins.

The 26S proteasome is the most complex ATP-dependent protease machinery, of ~2.5 MDa mass, ubiquitously found in all eukaryotes. It selectively degrades ubiquitin-conjugated proteins and plays fundamentally indispensable roles in regulating almost …

The 26S proteasome catalyzes the great majority (at least 80%) of the protein degradation in growing mammalian cells, including both the rapid degradation of misfolded and regulatory proteins and most of the slower breakdown of the bulk of cellular proteins (Zhao et al., 2015).

2008年8月8日 · Here we describe the three-dimensional structure of the human 26S proteasome, doubly capped with 19S-RPs, determined by single particle analysis of electron microscopy images.

In all eukaryotic cells, 26S proteasome plays an essential role in the process of ATP-dependent protein degradation. In this review, we focus on structure characterization of the 26S proteasome.