2019年2月4日 · MicroRNA-34 (miR-34) has been reported to be dysregulated in various human cancers and regarded as a tumor suppressive microRNA because of its synergistic effect with …

The dysregulation of the miR-34 family has been shown to play an important role in tumorigenesis and cancer progression. In this review, we summarized the current knowledge on the functions …

2009年5月22日 · Ectopic miR-34 expression induces apoptosis, cell-cycle arrest or senescence. In many tumor types the promoters of the miR-34a and the miR-34b/c genes are subject to …

2023年9月5日 · Here, we highlight a fully modified version of miR-34a (FM-miR-34a) that overcomes these hurdles when conjugated to a synthetically simplistic ligand.

2014年1月1日 · The miR-34 family consists of three members: miR-34a, miR-34b, and miR-34c; miR-34a is encoded by its own transcript, whereas miR-34b and miR-34c share a common …

MicroRNA-34 (miR-34) is a master regulator of tumor suppression. It is downregulated in numerous cancers and inhibits malignant growth by repressing genes involved in various …

2014年7月17日 · The miR-34 gene promoters contain p53-binding sites that are conserved among human, and, thus, leaves room for speculation of a p53-dependent regulation of the …

2014年9月23日 · The microRNA(miRNA)-34a is a key regulator of tumor suppression. It controls the expression of a plethora of target proteins involved in cell cycle, differentiation and …

2023年9月26日 · MicroRNA (miRNA) are small noncoding RNAs that play vital roles in post-transcriptional gene regulation by inhibiting mRNA translation or promoting mRNA …

MiR-34a is, in fact, a direct transcriptional target of p53 because the promoter region of miR-34a contains a canonical p53 binding site. 39 The p53 network suppresses tumor formation …