Tight junction protein ZO-1 also known as Zonula Occludens-1 (ZO-1), is a 220-kD peripheral membrane protein that is encoded by the TJP1 gene in humans. [5] It belongs to the family of zonula occludens proteins (ZO-1, ZO-2, and ZO-3), which are tight junction-associated proteins and of which, ZO-1 is the first

ZO-1 was the first tight junction protein to be discovered. 22 It is a cytosolic peripheral membrane protein with multiple domains specialized for protein interactions. Among these are three PDZ (PSD95/Dlg/ZO-1) domains, a Src homology-3 (SH3) domain, …

2021年7月22日 · Down-regulation of the tight junction protein ZO-1 in disease causes only mild increases in tight junction permeability but profoundly impairs mucosal healing.

ZO-1 makes critical, tight junction-independent contributions to Wnt signaling and mitotic spindle orientation. As a result, ZO-1 is essential for mucosal repair. We speculate that ZO-1 down-regulation may be one cause of ineffective mucosal healing in patients with IBD.

2024年12月25日 · TJP1 (Tight Junction Protein 1) is a Protein Coding gene. Diseases associated with TJP1 include Arrhythmogenic Right Ventricular Cardiomyopathy and Brain Edema. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Gene expression (Transcription).

2021年9月25日 · Zonula occludens-1 (ZO-1) was the first identified tight junction (TJ) protein and is a member of a large family of membrane-associated scaffolding and signaling molecules known as membrane-associated guanylate kinase homologues. 1 ZO-1 is conventionally regarded as forming a multidomain scaffold that coordinates the assembly of transmembrane ...

2024年5月23日 · Zonula occludens-1 (ZO-1) is involved in the regulation of cell-cell junctions between endothelial cells (ECs). Here we identify the ZO-1 protein interactome and uncover ZO-1 interactions...

Here, we demonstrate that the tight junction protein ZO-1 regulates tension acting on VE-cadherin–based adherens junctions, cell migration, and barrier formation of primary endothelial cells, as well as angiogenesis in vitro and in vivo.

ZO-1, a classical scaffold protein with accepted roles in maintaining cell-cell adhesions in stable tissues, also has an active role in cell migration during processes such as tissue development and remodelling.

In vitro and in vivo studies have linked downregulation of the scaffolding protein ZO-1, encoded by the TJP1 gene, to increased tight junction permeability. This has not, however, been tested in vivo. Here, we assessed the contributions of ZO-1 to …

2024年9月21日 · ZO-1，全称为zonula occludens-1，是这些紧密连接蛋白中的一种，其分子量约为220 kDa。 它位于细胞膜下，与其他紧密连接蛋白共同构建了细胞间连接的结构。 ZO-1蛋白不仅参与维持粘膜上皮机械屏障和通透性，还涉及调节细胞物质转运、维持上皮极性，并与细胞增殖分化、肿瘤细胞转移及基因转录等过程的信息传递和调控有关。 在细胞生物学中，ZO-1被视 …

Zonula occludens (ZO)-1 was the first tight junction protein to be cloned and has been implicated as an important scaffold protein. It contains multiple domains that bind a diverse set of junction proteins. However, the molecular functions of ZO-1 ...

2024年1月11日 · Our discoveries identified zonula occludens-1 (ZO-1) as a specific intrinsic molecule that plays a vital role in mediating the collective migration of MSCs towards breast tumor cells and...

ZO-1 has been demonstrated to interact with the transmembrane protein occludin, a second tight junction-specific MAGUK, ZO-2, and F-actin, although the nature and functional significance of these interactions is poorly understood.

Here, we demonstrate that the tight junction protein ZO-1 regulates tension acting on VE-cadherin–based adherens junctions, cell migration, and barrier formation of primary endothelial cells, as well as angiogenesis in vitro and in vivo.

Here, we examined the influence of each ZO protein (ZO-1, -2 and -3) on CD cell proliferation. We show that all 3 ZO proteins are strongly expressed in native CD and are present at both intercellular junctions and nuclei of cultured CD principal cells (mCCDcl1).

The junction-associated protein zonula occludens-1 (ZO-1) is a member of a family of membrane-associated guanylate kinase homologues thought to be important in signal transduction at sites of cell-cell contact. We present evidence that under certain ...

2009年7月15日 · ZO-1 binds numerous transmembrane and cytoplasmic proteins and is required for assembly of both adherens and tight junctions, but its role in defining barrier properties of an established tight junction is unknown.

2021年12月1日 · Increased permeability is implicated in the pathogenesis of intestinal disease. In vitro and in vivo studies have linked down-regulation of the scaffolding protein ZO-1, encoded by the TJP1 gene, to increased tight junction permeability. This …