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It was shown to be an essential protein in E. coli, implicated in cell envelope integrity, and to play a role in the delivery of LPS to the outer leaflet of the outer membrane. It works with LptB (formerly yhbG), a homolog of ABC transporter ATP-binding proteins, encoded by …

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In E. coli, LptC, LptA, and LptB (formerly known as YrbK, YhbN and YhbG, respectively) are encoded by the lptCAB locus, which is located downstream of genes involved in the biosynthesis of KDO (3-deoxy-d-manno-octulosonate), a component of the LPS inner core .

2020年10月2日 · YhbG is the putative ATP-binding cassette component and YhbN is the putative periplasmic-binding protein. Depletion of each gene product leads to growth arrest, irreversible cell damage and loss of viability in E. coli.

Here, we present evidence that two Escherichia coli essential genes, yhbN and yhbG, now renamed lptA and lptB, respectively, participate in LPS biogenesis.

Two recently identified genes involved in KDO biosynthesis, kdsD and kdsC, belong to the yrbG-yhbG locus where four additional ORFs (yrbG, yrbK, yhbN and yhbG) with unknown function are located.

2006年10月20日 · In this study, we provide evidence that YhbN and YhbG are implicated in the transport of LPS from the inner to the outer membrane of E. coli. Henceforth, yhbN and yhbG will be renamed lptA and lptB (for LPS transport), respectively.