2024年12月25日 · XRCC5 (X-Ray Repair Cross Complementing 5) is a Protein Coding gene. Diseases associated with XRCC5 include Werner Syndrome and Viral Exanthem. Among its related pathways are HIV Life Cycle and Infectious disease. Gene Ontology (GO) annotations related to this gene include RNA binding and transcription cis-regulatory region binding.

Gene ID: 7520, updated on 9-Feb-2025. The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5.

We used mice with a conditional deletion (cKO) of Xrcc5 in oocytes (Xrcc5 fl/fl; Gdf9 cre/+) to investigate the role of NHEJ and Ku80-dependent DNA repair during oocyte development and maturation. Mutant mice were confirmed to lack Xrcc5 mRNA expression in isolated oocytes by RT-PCR (Fig. 1A).

2023年9月7日 · XRCC5, a downstream gene of miRNA-188-5p, was reported to be upregulated in glioma samples. In contrast, miRNA-188-5p was down-regulated in these samples, and patients with glioma exhibiting low miRNA-188-5p expression levels showed higher rates of …

In this study, we identified XRCC5 as a binding protein of the COX-2 gene promoter in colon cancer cells with streptavidin-agarose pulldown assay and mass spectrometry analysis, and found that XRCC5 promoted colon cancer growth through modulation of COX-2 signaling.

2025年2月9日 · Title: Circular RNA XRCC5 aggravates glioma progression by activating CLC3/SGK1 axis via recruiting IGF2BP2. Centromeric protein K (CENPK) promotes gastric cancer proliferation and migration via interacting with XRCC5.

In this article, we have summarized the studies investigating the association between the XRCC5/XRCC6 dimer and the susceptibility to multiple cancers and discuss its role in carcinogenesis and its potential application to anticancer drug discovery.

2007年1月23日 · The XRCC5-XRRC6 dimer acts as a regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold (PubMed:11493912, PubMed:12145306, PubMed:20383123, PubMed:7957065, PubMed:8621488).

2010年5月26日 · The human XRCC5 DNA repair gene complements the radiosensitive mutant xrs-6, derived from Chinese hamster ovary cells which are defective in DNA double-strand break repair and in ability to undergo V (D)J recombination.

Gene: XRCC5 ENSG00000079246 Description X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) [Source:HGNC Symbol;Acc: 12833 ]