It encodes a protein showing 99% amino acid identity to the mouse Wnt7A protein. This gene not only guides the development of the anterior-posterior axis in the female reproductive tract but also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function.

2024年1月22日 · Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the...

2024年12月25日 · WNT7A (Wnt Family Member 7A) is a Protein Coding gene. Diseases associated with WNT7A include Ulna And Fibula, Absence Of, With Severe Limb Deficiency and Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Wnt …

Wnt7a regulates high autophagic and inflammatory response of epidermis in high-glucose environment. Roles of Wnt7a in embryo development, tissue homeostasis, and human diseases. Wnt7a, frequently silenced by CpG methylation, inhibits tumor growth and metastasis via suppressing epithelial-mesenchymal transition in gastric cancer.

2015年3月2日 · Here we identify Wnt7a as a novel upstream inducer of cellular senescence. In two different mouse strains (C57Bl/6J and FVB/NJ), we show that the loss of Wnt7a is a major contributing factor...

Although Wnt7a has been implicated in axon guidance and synapse formation, investigations of its role in the early steps of neurogenesis have just begun. We show here that Wnt7a is essential for neural stem cell self-renewal and neural progenitor cell cycle progression in …

Title: WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling. Down-regulated Wnt7a and GPR124 in early-onset preeclampsia placentas reduce invasion and migration of trophoblast cells.

2023年11月9日 · Through structural and functional analyses of Wnt7a, a crucial Wnt involved in central nervous system angiogenesis and blood-brain barrier maintenance, we have elucidated the principles of Wnt biogenesis and Wnt7-specific signaling.

2024年3月5日 · Wnt7a promotes the osteogenic differentiation of human mesenchymal stem cells. Exogenous Expression of WNT7A in Leukemia-Derived Cell Lines Induces Resistance to Chemotherapeutic Agents.

2024年12月19日 · Designated WNT7A, the gene encodes a deduced 349-amino acid polypeptide that has 98% and 64% sequence identity to mouse Wnt7a and human WNT5A (164975), respectively. Expression of the WNT7A gene is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.