2025年3月19日 · VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy. Tumour cells often evade immune …

2024年12月25日 · VDAC2 (Voltage Dependent Anion Channel 2) is a Protein Coding gene. Diseases associated with VDAC2 include Lateral Sclerosis and Alzheimer's Disease. Among …

6 天之前 · Removing VDAC2 in the presence of interferon-gamma increased cancer cell death directly and made tumors more inflammatory, thereby making tumors more vulnerable to …

Voltage Dependent Anion-selective Channel 2 (VDAC2) contributes to oxidative metabolism by sharing a role in solute transport across the outer mitochondrial membrane (OMM) with other …

Targeting VDAC2 in tumour cells enabled IFNγ-induced cell death and cGAS-STING activation, and markedly improved anti-tumour effects and immunotherapeutic responses. Using a …

2018年11月26日 · Deleting VDAC2 phenocopied the loss of BAX in impairing both the killing of tumor cells by anti-cancer agents and the ability to suppress tumor formation. Together, our …

VDACs are pore-forming proteins, coating the mitochondrial outer membrane, and playing the role of main regulators for metabolites exchange between cytosol and mitochondria. In mammals, …

2024年2月8日 · Channel conformational plasticity of mitochondrial VDAC2 controls its interaction kinetics with cytosolic proteins. In mammals, VDAC exists in three isoforms, VDAC1, VDAC2, …

VDAC2 is a new glycolytic regulator controlling the phenotype transition between glioma stem cells and non-stem cells and may serves as a new prognostic indicator and a potential …

2021年7月28日 · Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. …