USP22 controls cell growth and activation in different ways: it induces changes in promoter regions of genes by removing ubiquitin moieties from histones H2A and H2B leading to transcription activation; it induces cell cycle progression by the stabilization of cyclin B and TRF1 which induce cell mitosis and protection of telomeres during cell ...

2024年12月25日 · USP22 (Ubiquitin Specific Peptidase 22) is a Protein Coding gene. Diseases associated with USP22 include Spermatogenic Failure 64 and Spinocerebellar Ataxia 7. Among its related pathways are Chromatin organization and Deubiquitination.

Ubiquitin specific peptidase 22 is a protein that in humans is encoded by the USP22 gene on chromosome 17. [5] USP22 is known to function as a histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA.

Ubiquitin-specific peptidase 22 (USP22) is a deubiquitinating enzyme (DUB) that underlies tumorigenicity, proliferation, cell death and differentiation through deubiquitination of histone and non-histone targets.

2023年9月1日 · According to increasing evidence, USP22 appears to display a vital regulatory role in immune system through affecting the growth, development, and phenotypic switching of T cells and B cells. USP22 can deubiquitinate and stabilize NFATC2 to activate T cells and upregulate IL-2 release.

2021年8月28日 · USP22, an important member of the USP family, has been found to be closely associated with tumor cell cycle regulation, stemness maintenance, invasion and metastasis, chemoresistance, and immune regulation.

2021年8月28日 · USP22, an important member of the USP family, has been found to be closely associated with tumor cell cycle regulation, stemness maintenance, invasion and metastasis, chemoresistance, and immune regulation. We focus on recent advances regarding USP22's function in cancer and discuss the prospect of USP22 in this review. 1. Introduction.