2024年12月25日 · USP10 (Ubiquitin Specific Peptidase 10) is a Protein Coding gene. Diseases associated with USP10 include Schinzel-Giedion Midface Retraction Syndrome and Autism Spectrum Disorder. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and Deubiquitination.

2020年12月4日 · USP10 is a deubiquitinase involved in diverse cellular processes, including ubiquitin recycling, the DNA damage response, stress granule formation, and recycling of cellular proteins. USP10 can...

USP10 is a host factor that inhibits stress-induced reactive oxygen species production and apoptosis in HTLV-1-infected T cells. USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and USP13 by Beclin1 provides a mechanism for Beclin1 to control the levels of p53.

2018年11月30日 · We provide evidence that USP10/p62-induced protein aggregates inhibit proteasome activity, which increases the amount of ubiquitinated proteins and promotes aggresome formation. USP10 induced aggresomes containing α-synuclein, a pathogenic protein in Parkinson disease, in cultured cells.

Ubiquitin-specific peptidase 10 (USP10) is a member of the ubiquitin-specific protease family that removes the ubiquitin chain from ubiquitin-conjugated protein substrates.

2019年11月20日 · Taken together, our results demonstrate that USP10 is a critical regulator of KLF4, pinpointing USP10-KLF4-TIMP3 axis as a promising therapeutic target in lung cancer. Lung cancer is the leading...

2022年1月4日 · Here, we demonstrated that a deubiquitinase USP10, which specifically stabilizes nuclear AID protein, can translocate into the nucleus after AKT-mediated phosphorylation at its T674 within the...

Part of a ribosome quality control that takes place when ribosomes have stalled during translation initiation (iRQC): USP10 acts by removing monoubiquitination of RPS2/us5 and RPS3/us3, promoting 40S ribosomal subunit recycling (PubMed:34469731).

2020年11月10日 · USP10 (ubiquitin‐specific protease 10) protects against pressure overload‐induced cardiac hypertrophy. USP10 physically binds to sirtuin 6 and sirtuin 6 mediates the effect of USP10 on the regulation of cardiac hypertrophy. What Are the Clinical Implications?

2018年11月30日 · We provide evidence that USP10/p62-induced protein aggregates inhibit proteasome activity, which increases the amount of ubiquitinated proteins and promotes aggresome formation. USP10 induced aggresomes containing α-synuclein, a pathogenic protein in Parkinson disease, in cultured cells.