The TNF Family of Ligands and Receptors: Communication Modules ... - PubMed
2019年1月1日 · The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF) include 19 ligands and 29 receptors that play important roles in the …
On the TRAIL of Better Therapies: Understanding TNFRSF …
Tumor necrosis factor (TNF) superfamily ligands show diverse biological functions, such as the induction of apoptotic cell death or cell survival and proliferation, making them excellent …
The TNF Receptor Superfamily in Costimulating and Coinhibitory ...
Receptors in the TNFSF family activate diverse cellular functions, from production of type 1 interferons to the modulation of survival of antigen-activated T cells. Here, we focus attention …
Structural principles of tumor necrosis factor superfamily signaling …
Tumor necrosis factor (TNF) superfamily pathways regulate cell proliferation, cell death, and morphogenesis. TNF superfamily receptors mediate various cancers and immune-mediated …
Targeting the TNF and TNFR superfamilies in autoimmune disease …
2024年10月24日 · Here, we provide an overview of the past and current clinical trials targeting individual TNFSF or TNFRSF members in autoimmune and inflammatory disease and cancer. …
Clinical targeting of the TNF and TNFR superfamilies
2013年1月21日 · TNF receptor superfamily (TNFRSF) molecules contain variable numbers of cysteine-rich domains in their ligand-binding extracellular regions (ectodomains).
TNF superfamily control of tissue remodeling and fibrosis
Historically, tumor necrosis factor superfamily (TNFSF) ligands have been identified as proinflammatory mediators; however, our group has pioneered work implicating the TNF …
Antibody-Targeted TNFRSF Activation for Cancer Immunotherapy: …
2022年7月5日 · Tumor necrosis factor receptor superfamily (TNFRSF) members such as CD40, OX40 and CD137/4-1BB are expressed on myeloid cells and/or lymphocytes, and they …
On the TRAIL of Better Therapies: Understanding TNFRSF
2020年3月20日 · Tumor necrosis factor (TNF) superfamily ligands show diverse biological functions, such as the induction of apoptotic cell death or cell survival and proliferation, making …
TNFRSF receptor-specific antibody fusion proteins with targeting ...
2019年3月4日 · Antibodies specific for TNFRSF receptors that bind soluble ligands without getting properly activated generally act as strong agonists upon FcγR binding. Systematic analyses …
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