The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine -rich domain. [2][3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. [4] .

Tumor Necrosis Factor Receptor (TNFR) refers to a family of membrane proteins that play a crucial role in activating cell death pathways and regulating gene expression for cellular survival and differentiation.

2024年12月5日 · We hypothesized that free diffusion from random noise could generate shape-matched binders for challenging targets and tested this approach on TNFR1. We obtain designs with low picomolar affinity whose specificity can be completely switched to other family members using partial diffusion.

2021年1月25日 · Here we present a biochemical and structural characterisation of the small molecule-stabilised TNF-TNFR1 complex, providing insights into how a distorted TNF trimer can alter signalling...

2015年5月26日 · This Review focuses on the recent advances that have been made in understanding TNFR signalling and the consequences of its deregulation for cellular survival, apoptosis and regulated necrosis.

Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF) ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion, differentiation, and survival of antigen-primed CD4 + and CD8 + T cells and have a pivotal role in T-cell-medi …

2019年1月10日 · Increasing evidence suggests that thymus-derived, natural regulatory T cells (nTreg) express a remarkably high level of TNF Receptor 2 (TNFR2) and TNFα modulates the number or function of nTreg...

2000年8月1日 · TNF alpha exerts many of its effects by binding, as a trimer, to either a 55 kDa cell membrane receptor termed TNFR-1 or a 75 kDa cell membrane receptor termed TNFR-2. Both these receptors belong to the so-called TNF receptor superfamily. The superfamily includes FAS, CD40, CD27, and RANK.

2024年12月6日 · We hypothesized that free diffusion from random noise could generate shape-matched binders for challenging targets and tested this approach on TNFR1. We obtain designs with low picomolar affinity whose specificity can be completely switched to other family members using partial diffusion.

Following over two decades of clinical success for anti-TNF drugs, antagonists against multiple TNF/TNFR superfamily proteins are in development for IMIDs. This review explores the promise of these signaling molecules and highlights the opportunities and challenges in …