Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways.

2024年12月25日 · This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.

2010年1月19日 · Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment. Tumour necrosis factor (TNF)- α is a key...

2021年3月8日 · In this review, we briefly introduce the impact of TNF-α signaling on autoimmune diseases and its inhibitors, which are used as therapeutic agents against autoimmune diseases. Keywords: TNF-α; TNF-α inhibitors; autoimmune diseases; inflammatory bowel disease; psoriatic arthritis; rheumatoid arthritis.

TNFα signals through two transmembrane receptors, TNFR1 and TNFR2, and regulates a number of critical cell functions including cell proliferation, survival, differentiation, and apoptosis. Macrophages are the major producers of TNFα and interestingly are also highly responsive to …

2000年8月1日 · Tumour Necrosis Factor alpha (TNF alpha), is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and is responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis. The protein is also important for resistance to infection and cancers.

2022年11月15日 · Tumour necrosis factor (TNF) is a central cytokine in inflammatory reactions, and biologics that neutralize TNF are among the most successful drugs for the treatment of chronic inflammatory...

Tumor Necrosis Factor Alpha (TNF-α) is a cytokine that acts as an arbitrator of the local tissue environment following injury, and is involved in bone tissue regeneration. It can initiate apoptosis and regulate cell survival and proliferation.

2023年11月14日 · Tumor necrosis factor (TNF) is a protein you have in your body. It's important for your immune system to work the way it should to protect you. It's also involved in healing....

2021年3月8日 · Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the necrosis of tumors, but it has been recently identified to have additional important functions as a pathological component of autoimmune diseases. TNF-α binds to two different receptors, which initiate signal transduction pathways.