2024年12月25日 · TCL1A (TCL1 Family AKT Coactivator A) is a Protein Coding gene. Diseases associated with TCL1A include Leukemia and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are PI3K-Akt signaling pathway and PI3K / Akt Signaling. An important paralog of this gene is MTCP1.

T-cell leukemia/lymphoma protein 1A is a protein that in humans is encoded by the TCL1A gene. [5] [6] [7]

2023年3月23日 · Downregulated CDC20 in CLL cells resembles the aneuploidy phenotype and is associated with more aggressive disease and cellular features. Proposed integrative model of oncogenic TCL1A through the promotion of genomic instability in malignant B-cells.

Identification of T-cell leukemia and lymphoma protein overexpression in neoplasms. For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI).

2021年6月1日 · TCL1A has first been identified as an oncogene, overexpression of which is associated to the development of T and B cell cancer. TCL1A acts as a coactivator of the serine threonine kinase Akt and through other interactions favoring cell …

Distinct nuclear and cytoplasmic expression in subsets of immune cells in the mantle zone. Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.

2018年8月12日 · Almost 30 years ago, Carlo Croce's group discovered the T-Cell Leukemia/Lymphoma 1A oncogene (TCL1A or TCL1). TCL1 protein is normally expressed in fetal tissues and early developmental stage lymphocytes. Its expression is deregulated in chronic lymphocytic leukemia (B-CLL) and most lymphomas.

TCL1A - Explore an overview of TCL1A, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.

T-cell leukemia/lymphoma 1A (TCL1A; also known as TCL1) is a gene that encodes a protein that functions as a coactivator of AKT - a cell survival kinase. The protein is also important for the development of mature T cell leukemia.

To determine how TCL1 proteins cause cancer, it is crucially important that we determine the mechanisms of TCL1-family gene regulation and dysregulation, understand potential AKT-independent...