While there is broad evidence that direct TRPA1 stimulation in nociceptors mediates acute pain responses, recent findings have shifted the focus to the TRPA1 expressed in glial cells as the critical factor to sustain chronic pain.

TRPA1 mediates inflammation by inhibiting macrophage activation and inducing macrophage apoptosis. TRPA1 is upregulated in atherosclerotic plaques and modulates the transition of macrophages to an anti-inflammatory phenotype, thereby reducing atherosclerosis (Wang et …

TRPA1 is a non‐selective cation channel expressed in mammalian peripheral pain receptors, with a major role in chemonociception. TRPA1 has also been implicated in noxious cold and mechanical pain sensation.

2019年2月1日 · The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing neurons and other tissues and has become a major target in the development of novel pharmaceuticals. A remarkable feature of the channel is its long list of activators, many of which we are exposed to in dail …

The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation channel permeable to Ca (2+), Na (+), and K (+). TRPA1 is a promiscuous chemical nocisensor that is also involved in noxious cold and mechanical sensation.

2024年12月25日 · The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer.

2015年4月8日 · The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious chemical agents encountered in our environment or produced endogenously during tissue injury or drug...

2 天之前 · The transient receptor potential ankyrin 1 (TRPA1) non-selective cation channel can be activated by a hallmark of irritants and air-borne pollutants such as allyl-isothiocyanate (AITC) 1 ...

2019年9月9日 · TRPA1 is a calcium ion (Ca 2+)-permeable non-selective cation channel that is expressed in a set of nociceptive/thermo-receptive neurons that can detect noxious cold temperatures below 17°C.

Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation. Functional TRPA1 Channels Regulate CD56 [dim]CD16 [+] NK Cell Cytotoxicity against Tumor Cells. [TRPA1 channel mediates oxidative stress defense in cancer].