The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from …

您可点击此处下载 TNF receptor-associated factor 6（TRAF6）靶点介绍及 WB 实验小贴士 pdf 文件。

TRAF6（TNF receptor associated factor 6）是一个泛素连接酶（ubiquitin-ligase），当它被激活的时候，会在自身和其它蛋白上产生短小蛋白链。因此TRAF6作为一个开关，能够决定在细胞内开启何种信号。

NF-κB was first identified in 1986 as a B cell-specific transcription factor inducing immunoglobulin κ light chain expression. Subsequent studies revealed that NF-κB plays important roles in development, organogenesis, immunity, inflammation, and ...

Tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6) is an adaptor protein that mediates a wide array of protein-protein interactions via its TRAF domain and a RING finger domain that possesses non-conventional E3 ubiquitin ligase ...

TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NF-κB activation NF-κB was first identified in 1986 as a B cell-specific transcription factor inducing immunoglobulin κ light chain expression. Subsequent studies revealed that NF-κB plays important roles in development, organogenesis, immunity, …

TNF 受体相关因子 6： 该基因编码的蛋白质是 TNF 受体相关因子 (TRAF) 蛋白质家族的成员。 TRAF 蛋白与 TNF 受体超家族成员相关并介导其信号转导。这种蛋白质有一个氨基末端环结构域，其后是四个锌指基序、一个中央卷曲螺旋区域和一个高度保守的羧基末端结构域，称为 TRAF-C 结构域，并介导来自 TNF ...

肿瘤坏死因子受体相关因子 (tumor necrosis factor receptor-associated factors, TRAF)是一类重要的具有多功能的细胞内信号转导因子。TRAF参与多种受体家族的信号转导，包括肿瘤坏死因子受体家族 (tumor necrosis factor receptor, TNFR)和Toll样-IL-1受体 (Toll-like receptors-interleukin-1 receptors,TLR-IL-1R)家族等，在固有免疫和获得 ...

2024年12月25日 · TRAF6 (TNF Receptor Associated Factor 6) is a Protein Coding gene. Diseases associated with TRAF6 include Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant and Hypophosphatasia, Adult. Among its related pathways are Toll Like Receptor 3 (TLR3) Cascade and p75 NTR receptor-mediated signalling. Gene Ontology (GO) …

Abstract Tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6) is a crucial signaling molecule regulating a diverse array of physiological processes, including adaptive immunity, innate immunity, bone metabolism and the development of several tissues including lymph nodes, mammary glands, skin and the central nervous system. It is a member of a group of six closely …