2024年12月25日 · TCF7L2 (Transcription Factor 7 Like 2) is a Protein Coding gene. Diseases associated with TCF7L2 include Type 2 Diabetes Mellitus and Autism. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and ncRNAs involved in Wnt signaling in hepatocellular carcinoma.

TCF7L2 regulates adipocyte size, adipocyte endocrine function, and glucose metabolism. TCF7L2 expression in white adipose tissue is suppressed in genetic and high fat diet–induced models of obesity.

TCF7L2 is the most potent locus for type 2 diabetes (T2D) risk and the first locus to have been robustly reported by genomic linkage studies. TCF7L2 is a transcription factor that forms a basic part of the Wnt signaling pathway.

TCF7L2 variants provide an experiment of nature that will allow these and other vital questions about diabetes pathogenesis to be addressed.

TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR. TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes. Role of EPO and TCF7L2 Gene Polymorphism Contribution to the Occurrence of Diabetic Retinopathy.

TCF7L2 is a transcriptional regulator of the canonical Wnt‐signaling pathway, a major transducer of β‐catenin activity. It also regulates cell fate specification during development and cell proliferation (Clevers, 2006; Köttgen et al., 2008; MacDonald et al., 2009; Peifer & Polakis, 2000).

2009年11月23日 · The TCF7L2 variant rs7903146 appears to affect risk of type 2 diabetes, at least in part, by modifying the effect of incretins on insulin secretion. This is not due to reduced secretion of GLP-1 and GIP but rather due to the effect …

2024年5月5日 · TCF7L2 transcription factor 7 like 2 Gene ID: 6934, updated on 5-May-2024 Gene type: protein coding Also known as: TCF4; TCF-4. See all available tests in GTR for this gene; Go to complete Gene record for TCF7L2; Go to …

2007年8月1日 · Transcription factor-7–like 2 (TCF7L2) is the most important type 2 diabetes susceptibility gene identified to date, with common intronic variants strongly associated with diabetes in all major racial groups.

The TCF7L2 protein is a key transcriptional effector of the Wnt/β-catenin signaling pathway, regulating gene expression. It was initially identified in cancer research and embryologic developmental studies.