TAS2R38 is a bitter taste receptor; varying genotypes of TAS2R38 influence the ability to taste both 6- n -propylthiouracil (PROP) [5] and phenylthiocarbamide (PTC). [6][7] Though it has often been proposed that varying taste receptor genotypes could influence tasting ability, TAS2R38 is one of the few taste receptors shown to have this function.

Here we studied the distribution of TAS2R38 haplotypes in a large number of human populations and available archaic hominid genomes to provide a fine-scale view of worldwide TAS2R38 diversity, and we applied selection tests to evaluate the processes underlying the evolution of TAS2R38 haplotypes.

2016年5月3日 · The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene.

2019年12月2日 · Here we evaluated the role of the bitter receptor TAS2R38 in attainment of longevity, since it has been widely associated with individual differences in taste perception, food preferences, diet,...

2025年3月8日 · Gene target information for TAS2R38 - taste 2 receptor member 38 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

The TAS2R38 gene is widely responsible for the well-known bimodal response to a family of bitter chemicals which includes 6- n -propylthiouracial (PROP). There are two common haplotypes of this gene, the recessive AVI and the dominant PAV, both of which are well studied.

2019年7月25日 · TAS2R38 is known as the bitter taste gene and it affects an individual’s response to taste bitter foods, with polymorphisms in the bitter taste receptor gene (TAS2R38) altering the ability to sense the intensity of bitterness of phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).

The human TAS2R38 gene encodes a bitter taste receptor that regulates the bitterness perception and differentiation of ingested nutritional/poisonous compounds in the oral cavity and gastrointestinal tract.

2024年12月25日 · TAS2R38 (Taste 2 Receptor Member 38) is a Protein Coding gene. Diseases associated with TAS2R38 include Thiourea Tasting and Dental Caries. Among its related pathways are GPCR downstream signalling and Sensory perception of taste.

TAS2R38 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (summary by Conte et al., 2002). For further information on the TAS2R gene family, see 604791. Cloning and Expression