The Philadelphia chromosome or Philadelphia translocation (Ph) is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells).

2011年11月18日 · The Philadelphia chromosome (Ph), t(9;22), is detected in around 90% of the chronic myeloid leukemia (CML) patients, but in the remaining 5–10% cases a variant type may be present. Variant Ph-chromosome is characterized by the involvement of another chromosome in addition to the 9 and 22.

2000年10月1日 · Evidence exists for the involvement of the most primitive and quiescent hematopoietic stem cell compartiment (CD34+/CD38-, Thy1+): t (9;22) is found in myeloid progenitor and in B-lymphocytes progenitors, but, involvement of the T …

Chronic myeloid leukemia is caused by a rearrangement (translocation) of genetic material between chromosome 9 and chromosome 22. This translocation, written as t (9;22), fuses part of the ABL1 gene from chromosome 9 with part of the BCR gene from chromosome 22, creating an abnormal fusion gene called BCR-ABL1.

2019年4月23日 · The Philadelphia (Ph) chromosome, resulting from the t(9;22)(q34;q11) translocation, can be found in chronic myeloid leukemia (CML) as well as in a subset of acute lymphoblastic leukemias (ALL).

2017年5月12日 · Overall, 19 children (6.3%) presented with additional cytogenetic findings at diagnosis: 5 children (1.7%) had a variant t (9;22) translocation, 13 children (4.3%) had ACAs, and 1 had both.

2016年5月27日 · The truncated chromosome 22 that results from the reciprocal translocation t(9;22)(q34;q11) is known as the Philadelphia chromosome (Ph) and is a hallmark of chronic myeloid leukemia (CML). In leukemia cells, Ph not only impairs the physiological signaling pathways but also disrupts genomic stability.

2009年10月30日 · t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome – Ph +) determine formation of different fusion genes that are associated with either Ph + acute lymphatic leukemia (Ph …

A translocation between chromosome 9 and chromosome 22 that may be associated with Philadelphia chromosome and increased susceptibility to several types of leukemia.

2000年2月1日 · We found that a substantial minority of patients with CML had large acquired genomic deletions resulting in loss of chromosome 9 and 22 sequences flanking the translocation breakpoint on the derivative 9, on additional partner chromosomes, or on both.