2024年12月25日 · Complete information for SLC7A8 gene (Protein Coding), Solute Carrier Family 7 Member 8, including: function, proteins, disorders, pathways, orthologs, and expression.

2022年11月16日 · These findings identify Slc7a8 as a key supplier of amino acids for the metabolic programs underpinning fitness and activation of ILC2s. Keywords: allergy; amino acid; asthma; innate lymphoid cells; transporter.

2025年2月8日 · The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer. These preliminary data suggest that a relevant proportion of age-related hearing loss cases could be explained by SLC7A8 mutations.

Mechanistically, Slc7a8 deficiency impaired ILC2 functions via mitochondrial OXPHOS, mTOR signaling, and c-Myc expression. We conclude that SLC7A8 is a key supplier of amino acids for the metabolic programs that sustain fitness and activation of ILC2s.

2024年1月18日 · SLC7A8 expression in LUAD was significantly correlated with the infiltration of immune cells, especially B cells, interstitial dendritic cells, mast cells, CD56 bright cells, natural killer cells, plasmacytoid dendritic cells, T follicular helper cells, T helper 2 and 17 cells, and immune factors.

2024年12月10日 · The solute carrier SLC7A8 is a marker of favourable prognosis in ER-positive low proliferative invasive breast cancer. El Ansari R, et al. Breast Cancer Res Treat, 2020 May.

2022年2月16日 · This study demonstrates that targeting slc7a8 protects against diet-induced obesity by reducing lipid accumulation in multiple organs and suggests that if targeted, has the potential to mitigate the development of obesity-associated comorbidities.

2025年2月8日 · Gene ID: 50934, updated on 8-Feb-2025. Enables glycine transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Involved in carboxylic acid transport and thyroid hormone transport. Acts upstream of or within L-amino acid transport. Located in apical plasma membrane.

Here, we report findings from targeting a novel potential human adipogenic gene (SLC7A8) under conditions of obesity development using a mouse model of diet-induced obesity (DIO). The results indicate that deleting slc7a8 in mice significantly protects …

Here, we show that SLC7A8 is the key amino acid transporter in ILC2s. Slc7a8 deletion in lymphocytes reduced ILC2s and attenuated responses to helminth infection and house dust mite allergens.