2024年2月21日 · SIRT7 distinguishes itself as the exclusive mammalian Sirtuin primarily localized within the nucleolus, a crucial organelle involved in ribosome biogenesis. In this compartment, SIRT7...

2024年12月25日 · SIRT7 (Sirtuin 7) is a Protein Coding gene. Diseases associated with SIRT7 include Lysosomal Storage Disease and Prostate Cancer. Among its related pathways are NAD metabolism and p53 Signaling. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone H3K18 deacetylase activity, NAD-dependent.

2025年2月4日 · We show that the SIRT7 N-terminus represents a unique, extended nucleosome-binding domain, reaching across the nucleosomal surface to the acidic patch. The catalytic domain binds at the H3-tail...

2016年7月20日 · Here we report that SIRT7 is an NAD + -dependent histone desuccinylase. We show that SIRT7 is recruited to DNA double-strand breaks (DSBs) in a PARP1-dependent manner and catalyses...

SIRT7, a member of the sirtuin family of NAD +-dependent protein deacetylases, is a key mediator of many cellular activities. SIRT7 expression is linked to cell proliferation and oncogenic activity, connecting SIRT7-dependent regulation of ribosome biogenesis with checkpoints controlling cell cycle progression, metabolic homeostasis, stress ...

2024年1月1日 · SIRT7, the most recently identified member of the SIRTs, maintains physiological homeostasis and provides protection against aging by functioning as a watchdog of genomic integrity, a dynamic sensor and modulator of stresses.

SIRT7 is one of seven mammalian sirtuins that functions as an NAD+-dependent histone/protein deacetylase. SIRT7 is the least well-known member of the sirtuin family, but recent efforts have identified its involvement in various cellular processes, ...

2023年12月25日 · SIRT7 is the least well-studied member of the sirtuins, but accumulating evidence has shown that SIRT7 plays critical roles in the regulation of glucose and lipid metabolism by modulating many target proteins in white adipose tissue, brown adipose tissue, and liver tissue.

SIRT7 distinguishes itself as the exclusive mammalian Sirtuin primarily localized within the nucleolus, a crucial organelle involved in ribosome biogenesis. In this compartment, SIRT7 cooperates with SIRT1 to uphold the stability of silenced rDNA genes in untransformed cells.

3 天之前 · SIRT7, one of the least studied members of the Sirtuins family, is an NAD+-dependent lysine deacetylase and desuccinylase. While previous studies using affinity enrichment and quantitative ...