2024年12月25日 · SESN2 (Sestrin 2) is a Protein Coding gene. Diseases associated with SESN2 include Pulmonary Emphysema and Autism Spectrum Disorder. Among its related pathways are Gene expression (Transcription) and Cellular responses to stimuli. An important paralog of this gene is SESN1.

2023年2月25日 · SESN2 is a stress-responsive protein with a distinct molecular structure regulating mTORC1. SESN2 is involved in multiple pathophysiological events, such as hypoxia, genotoxic stress,...

Sestrin2 (SESN2), a highly evolutionarily conserved protein, is critically involved in cellular responses to various stresses. SESN2 has a protective effect on physiological and pathological states mainly via regulating oxidative stress, endoplasmic ...

2022年1月3日 · SESN2, known as hypoxia-inducible gene 95, is upregulated in cells under hypoxic conditions as well as oxidative stress, DNA damage, endoplasmic reticulum stressors, starvation, and high-fat diet [6, 7, 8]. It has also been identified as a key leucine sensor for the mTORC1 pathway in mammalian cells [9, 10].

2021年2月1日 · Sestrin2 (Sesn2) is a powerful anti-oxidant that can prevent acute and chronic diseases. The role of Sesn2 has been thoroughly reviewed in liver, nervous system, and immune system diseases.

In this review, we discuss the physiological and pathophysiological roles and signaling pathways of Sesn2 in different stress-related conditions, such as oxidative stress, genotoxic stress, and hypoxia. Sesn2 is also involved in aging, cancer, diabetes, and ischemic heart disease.

SESN2 is a member of the evolutionarily conserved sestrin protein family found in most of the Metazoa species. The SESN2 gene is transcriptionally activated by many stress factors, including metabolic derangements, reactive oxygen species (ROS), and DNA-damage. As a result, SESN2 controls ROS accumulation, metabolism, and cell viability.

2021年9月4日 · Sestrin2 (Sesn2), a highly evolutionary and stress-responsive protein, is critically involved in defense against oxidative stress challenges.

2024年12月10日 · Gene target information for SESN2 - sestrin 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

2019年12月3日 · Sestrin2 (SESN2), a highly evolutionarily conserved protein, is critically involved in cellular responses to various stresses. SESN2 has a protective effect on physiological and pathological states mainly via regulating oxidative stress, endoplasmic reticulum stress, autophagy, metabolism, and inflammation.