Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. [5] [6] [7] In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. [5]

2025年2月8日 · SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. SIRT6 is upregulated in both paclitaxel-resistant and epirubicin-resistant MCF-7 cells. SIRT6 plays a role in regulating the terminal effector pathways of human labor and delivery via the NFKB pathway.

2023年1月18日 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global...

SIRT6, a member of the Sirtuin family of NAD + -dependent enzymes, has established roles in chromatin signaling and genome maintenance. Through these functions, SIRT6 protects against aging-associated pathologies including metabolic disease and …

SIRT6 is a longevity protein that can inhibit the aging of cells, tissues, organs and the body by promoting DNA damage repair (5 – 7), maintaining normal chromosome structure (8 – 10), and regulating energy metabolism (11, 12) and the senescence-associated secretory phenotype (SASP) (13, 14).

The biological functions of SIRT6 (e.g. deacetylation, defatty-acylation and mono-ADP-ribosylation) play a pivotal role in regulating lifespan and several fundamental processes controlling aging such as DNA repair, gene expression, and telomeric ...

Sirtuin 6 (SIRT6) is an NAD+-dependent protein deacylase and mono-ADP-ribosyltransferase of the sirtuin family with a wide substrate specificity. In vitro and in vivo studies have indicated that SIRT6 overexpression or activation has beneficial ...

2008年3月12日 · Here we show that the human SIRT6 protein is an NAD + -dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres, and...

2021年5月28日 · Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice. A combination of physiological assays, in vivo multi-omics analyses...

2011年4月4日 · SIRT6 is a member of the evolutionarily conserved sirtuin family of NAD + -dependent protein deacetylases and functions in genomic stability and transcriptional control of glucose metabolism. Early reports suggested that SIRT6 performs ADP-ribosylation, whereas more recent studies have suggested that SIRT6 functions mainly as a histone deacetylase.