SIRT2 sensitizes cells to the action of insulin by physically interacting with and activating Akt and downstream targets. SIRT2 mediates mitochondrial biogenesis by deacetylating PGC-1α, upregulates antioxidant enzyme expression by deacetylating …

Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the cytoplasm but is also found in the mitochondria and in the nucleus.

2024年12月25日 · SIRT2 (Sirtuin 2) is a Protein Coding gene. Diseases associated with SIRT2 include Thrombocytopenia and Retinoblastoma. Among its related pathways are Cell Cycle, Mitotic and NAD metabolism. Gene Ontology (GO) annotations related to this gene include chromatin binding and histone deacetylase binding. An important paralog of this gene is SIRT3.

Sirtuin 2 (SIRT2), as a member of the sirtuin family, has representative features of evolutionarily highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase activity. In addition, SIRT2, as the only sirtuin protein colocalized ...

As a type of nicotinamide adenine dinucleotide (NAD +)-dependent deacetylases, sirtuin 2 (SIRT2) is predominantly found in the cytoplasm of cells in the central nervous system (CNS), suggesting its potential role in neurological disorders.

Human sirtuin 2 (SIRT2) is an NAD +-dependent deacetylase that primarily functions in the cytoplasm, where it can regulate α-tubulin acetylation levels. SIRT2 is linked to cancer progression, neurodegeneration, and infection with bacteria or viruses.

SIRT2 inhibits colony formation in glioma cell lines (Hiratsuka et al., 2003) and arrests chromosomal instability by getting down-regulated. SIRT2 is associated with neurodegenerative diseases, and its inhibition delays the progression of the disease.

Sirtuin 2 (Sirt2) is a member of the sirtuin family of NAD-dependent lysine deacylases and plays important roles in regulation of the cell cycle and gene expression. As a nucleocytoplasmic deacetylase, Sirt2 has been shown to target both histone and …

2023年10月2日 · SIRT2 was identified as a key protein decreased in aged monkey hearts, and engineered SIRT2 deficiency in human pluripotent stem cell-derived cardiomyocytes recapitulated key senescence...

2019年11月1日 · Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the cytoplasm but is also found in the mitochondria and in the nucleus.