RANTES (regulated on activation, normal T cell expressed and secreted), one of the natural ligands for CCR5, is a broadly active inhibitor of macrophage infection by R5 HIV-1 isolates.

RANTES (regulated upon activation, normal T cell expressed and secreted [also known as CCL5]) is a model chemokine of relevance to a myriad of diseases. Regulation of RANTES expression is complex. In fibroblasts and monocytes, rel proteins alone …

CCL5，CC类趋化因子配体5，也称为调节激活正常T细胞表达分泌因子（RANTES），是一种能使白细胞作定向移动的小分子分泌蛋白。 CCL5来源广泛，如NK、T、巨噬细胞、滑膜成纤维细胞，炎症反应中的CD8+ T细胞、上皮细胞、成纤维细胞和血小板，病毒感染后的细胞，以及某些肿瘤细胞。 CD40、IL-15等不同刺激物激活NF-kB会诱导CCL5的产生。 CCL5招募多种白细胞（ …

2001年2月1日 · The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication.

The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. …

Here we report that in experimental studies RANTES and MCP-1 provoke mast cell activation and increase histidine decarboxylase mRNA expression in a dose-dependent manner. Moreover, injections of RANTES and MCP-1 in the rat skin cause mast cell, eosinophil, and macrophage recruitment, and prostaglandin E2 (PGE2) generation.

Explore the role of CCL5 (RANTES), a crucial chemokine involved in immune responses, inflammation, and various diseases. Learn about its function, regulation, clinical significance, and potential therapeutic applications.

At low concentrations, RANTES acts in a monomeric (or dimeric) form directly on its specific chemokine receptors; at high concentrations, it self-aggregates and acts through interactions with cell-surface glycosaminoglycans.

2007年2月27日 · We learn now from Wu and colleagues 10 in this issue of Circulation that T cells and the chemokine CCL5/regulated on activation, normal T cell expressed and secreted (RANTES) are also increased in WAT in the setting of murine and human obesity (Figure).

RANTES is a CC chemokine expressed late in allografts following transplantation that binds CCR1 and CCR5 on T cells, NK cells and macrophages. RANTES is expressed in rat lung and mouse heart and skin allografts but not in isografts [25].