ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major …

Rho-associated kinases ROCK1 and ROCK2 are serine/threonine kinases that are downstream targets of the small GTPases RhoA, RhoB, and RhoC. ROCKs are involved in diverse cellular …

2024年12月25日 · ROCK1 (Rho Associated Coiled-Coil Containing Protein Kinase 1) is a Protein Coding gene. Diseases associated with ROCK1 include Breast Cancer and Lung Cancer. …

2025年2月8日 · ROCK1 in bone marrow-derived cells is a critical mediator of atherogenesis; macrophage ROCK1 may be an important therapeutic target for vascular inflammation and …

The Rho kinase (ROCK) isoforms, ROCK1 and ROCK2, were initially discovered as downstream targets of the small GTP-binding protein Rho. Because ROCKs mediate various important …

Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase effectors that control key aspects of the actin cytoskeleton, but their role in proliferation and cancer initiation or progression is not …

ROCK1 is a protein that was discovered as a downstream target of the small GTP-binding protein RhoA. It plays a significant role in mediating cell motility, proliferation, apoptosis, and the …

ROCK1 but not LIMK1 or PAK2 is a key regulator of apoptotic membrane blebbing and cell disassembly. ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating …

2013年7月23日 · These results show that ROCK1 acts as a prominent upstream regulator of Beclin1-mediated autophagy and maintains a homeostatic balance between apoptosis and …

Rho-associated coiled-coil–forming protein kinase (ROCK) isoform ROCK1 and/or ROCK2 expression is reduced in ROCK1-haploinsufficient (ROCK1 +/−), ROCK2-haploinsufficient …