Targeting RIPK1 for the treatment of human diseases - PMC
RIPK1 has emerged as a promising target for a spectrum of human CNS and peripheral pathologies. RIPK1 activity is tightly controlled by multiple layers of regulatory factors that we …
Development of a RIPK1 degrader to enhance antitumor immunity
2024年12月16日 · Degradation of RIPK1 by LD4172 triggers immunogenic cell death, enhances tumor-infiltrating lymphocyte responses, and sensitizes tumors to anti-PD1 therapy in female …
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic …
2020年8月20日 · This article reviews RIPK1 biology and disease-associated mutations in RIPK1 signalling pathways, highlighting clinical trials of RIPK1 inhibitors and potential strategies to …
RIPK1 Gene - GeneCards | RIPK1 Protein | RIPK1 Antibody
2024年12月25日 · This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell …
Roles of RIPK1 as a stress sentinel coordinating cell survival and ...
2023年8月11日 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is emerging as a critical stress sentinel that functions as a molecular switch, governing cellular survival,...
RIPK1 in necroptosis and recent progress in related pharmaceutics
Receptor-interacting serine/threonine protein kinase l (RIPK1) is a crucial protein kinase that regulates the necroptosis pathway. Increased expression of death receptor family ligands such …
Palmitoylation licenses RIPK1 kinase activity and cytotoxicity in …
2024年10月28日 · Our findings reveal that ubiquitination-dependent palmitoylation licenses RIPK1 kinase activity to induce downstream cell death signaling and suggest RIPK1 palmitoylation as …
The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell …
2024年7月9日 · RIPK1 regulates cell death via kinase-dependent and kinase-independent mechanisms. Utilizing mice expressing RIPK1 with a point mutation disrupting its death …
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
2020年7月15日 · Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a master regulator of the cellular decision between pro-survival NF-κB signalling and death in response …
RIPK1 receptor interacting serine/threonine kinase 1 [ (human)]
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis. RIP1 kinase activity promotes steatohepatitis through mediating cell death and inflammation in …
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