2024年12月25日 · Complete information for RGS4 gene (Protein Coding), Regulator Of G Protein Signaling 4, including: function, proteins, disorders, pathways, orthologs, and expression.

Regulator of G protein signaling 4 (Rgs4) is a signal transduction protein that controls the function of monoamine, opiate, muscarinic, and other G protein-coupled receptors via interactions with Gα subunits.

RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms. Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4.

2021年6月25日 · The Regulator of G protein signaling 4 (Rgs4) is a member of the RGS proteins superfamily that modulates the activity of G-protein coupled receptors.

Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of Gα-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia susceptibility factor.

We show that RGS4 is a pleiotropic inhibitor of epithelial and endothelial cell tubulogenesis, doing so by inhibiting G protein- and VEGF-mediated activation of MAP kinases (e.g., ERK1/ERK2 and p38 MAPK), which results in diminished cell proliferation, migration, and invasion.

2021年6月25日 · The Regulator of G protein signaling 4 (Rgs4) is a member of the RGS proteins superfamily that modulates the activity of G-protein coupled receptors. It is mainly expressed in the nervous system and is linked to several neuronal signaling pathways; however, its role in neural development in vivo rem …

We show that RGS4 is a pleiotropic inhibitor of epithelial and endothelial cell tubulogenesis, doing so by inhibiting G protein- and VEGF-mediated activation of MAP kinases (e.g., ERK1/ERK2 and p38 MAPK), which results in diminished cell proliferation, migration, and invasion.

2020年12月22日 · This was achieved by pharmacological targeting of the Regulator of G protein Signalling 4 (RGS4). RGS proteins inhibit signal transduction pathways initiated by G protein-coupled receptors (GPCR) by enhancing GPCR deactivation and receptor desensitisation.

ENCODES a protein that exhibits G-protein alpha-subunit binding; GTPase activator activity; protein kinase binding; INVOLVED IN dorsal root ganglion development; negative regulation of cell growth involved in cardiac muscle cell development; negative regulation of dopamine receptor signaling pathway; PARTICIPATES IN acetylcholine signaling pathway via muscarinic …