The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. [5] One …

2024年12月25日 · Complete information for RB1 gene (Protein Coding), RB Transcriptional Corepressor 1, including: function, proteins, disorders, pathways, orthologs, and expression.

2020年4月2日 · The retinoblastoma tumor suppressor gene (RB1) plays a critical role in coordinating multiple pathways that impact cancer initiation, disease progression, and …

2024年6月19日 · This overview delves into the role of RB1 in both health and disease, exploring its association with the tumourigenesis of various cancers and a distinct subset of soft-tissue …

2006年8月28日 · Hereditary retinoblastoma is caused by germline transmission of one mutationally inactivated Rb1 allele and loss of the remaining wild-type allele in somatic retinal …

2025年3月4日 · Gene target information for RB1 - RB transcriptional corepressor 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay …

RB1 deficiency makes the retinoblastoma cell-of-origin extremely susceptible to cancerous transformation, and the tumor cell-of-origin appears to depend on the developmental stage …

The RB1 gene is the first tumor suppressor gene identified whose mutational inactivation is the cause of a human cancer, the pediatric cancer retinoblastoma. The 25 years of research since …

The RB1 gene provides instructions for making a protein called pRB. This protein acts as a tumor suppressor, which means that it regulates cell growth and keeps cells from dividing too fast or …

2023年12月20日 · Understanding the functions and mutations of the Rb1 gene is essential for developing targeted therapies and improving the diagnosis and treatment of various cancers. …