PU.1 is an essential regulator of the pro-fibrotic system. In fibrotic conditions , PU.1 expression is perturbed in fibrotic diseases, resulting in upregulation of fibrosis-associated genes sets in …

PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews …

2010年6月3日 · This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by …

2005年9月1日 · By using a conditional PU.1 knock-out model, we here show that HSCs express PU.1, and its constitutive expression is necessary for maintenance of the HSC pool in the …

PU.1 is an E26 transformation-specific family transcription factor that is required for development of the immune system. PU.1 functions at both early and late stages of lymphoid and myeloid …

2020年1月21日 · Nature Communications - PU.1 is a master TF of hematopoietic lineage differentiation. Here the authors analyse properties of PU.1 DNA-binding in vitro and genome …

PU.1 is a member of the transcription factor family Ets that is expressed selectively on B cells, myeloid cells and macrophages. PU.1 regulates the expression of several genes, including …

2019年1月15日 · We found that conditional ablation of the Ets-family transcription factor PU.1 in DC-restricted progenitors led to increased pDC production at the expense of cDCs. PU.1 …

The haematopoietic-specific Ets family transcription factor PU.1 regulates many lymphoid- and myeloid-specific gene promoters and enhancers by interacting with multiple proteins during …

PU.1 is essential for terminal myeloid cell differentiation, B and T cell development, erythropoiesis and hematopoietic stem cell maintenance. These pleiotropic functions are reflected by its …