Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene. [5][6] The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases.

2024年12月25日 · PTPN14 (Protein Tyrosine Phosphatase Non-Receptor Type 14) is a Protein Coding gene. Diseases associated with PTPN14 include Choanal Atresia And Lymphedema and Lymphedema-Posterior Choanal Atresia Syndrome .

PTPN14 acts as a candidate tumor suppressor in prostate cancer and inhibits cell proliferation and invasion through modulating LATS1/YAP signaling. PTPN14 deficiency alleviates podocyte injury through suppressing inflammation and fibrosis by targeting TRIP6 in diabetic nephropathy.

2024年8月27日 · PTPN14 overexpression exacerbates neointimal hyperplasia in a phosphatase activity-dependent manner, while SMC-specific deficiency of PTPN14 mitigates this process in mice. RNA-seq indicates...

2024年8月27日 · PTPN14 overexpression exacerbates neointimal hyperplasia in a phosphatase activity-dependent manner, while SMC-specific deficiency of PTPN14 mitigates this process in mice. RNA-seq indicates that PTPN14 deficiency inhibits PDGFRβ signaling-induced SMC phenotypic modulation.

2023年3月10日 · By overexpression or knockdown of PTPN14, we demonstrated that PTPN14 could promote gastric cancer proliferation, migration, and invasion. Furthermore, the FERM domain of PTPN14 was the key...

2019年1月4日 · HGNC Approved Gene Symbol: PTPN14. Cytogenetic location: 1q32.3-q41 Genomic coordinates (GRCh38) : 1:214,348,700-214,551,602 (from NCBI) Protein-tyrosine phosphorylation is regulated by the activities of the protein-tyrosine kinases (PTKs) and the protein-tyrosine phosphatases (PTPs).

2024年6月21日 · In this study, a genome-wide CRISPR/Cas9 knockout screen in TNBC cells has identified tyrosine-protein phosphatase nonreceptor type 14 (PTPN14) as a key regulator of anoikis resistance. PTPN14 expression has shown a progressive decrease from normal breast tissue to metastatic tumors.

2024年12月10日 · Recurrent PTPN14 Mutations in Trichilemmoma: Evidence for Distinct Pathways of Molecular Pathogenesis. Russell-Goldman E, Dong F, Hanna JRussell-Goldman E, et al. Am J Dermatopathol, 2022 Aug 1. PMID 35830698; Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution.

2010年9月10日 · We report the results of genetic analyses of a kindred inheriting a unique autosomal-recessive lymphedema-choanal atresia syndrome. These studies establish linkage of the trait to chromosome 1q32-q41 and identify a loss-of-function mutation in PTPN14, which encodes a nonreceptor tyrosine phosphatase.