Protein post-translational modifications (PTMs) increase the functional diversity of the proteome by the covalent addition of functional groups or proteins, proteolytic cleavage of regulatory …

Posttranslational modifications (PTMs) are covalent processing events that change the properties of a protein by proteolytic cleavage and adding a modifying group, such as acetyl, phosphoryl, …

2015年2月20日 · These modifications include acylation, methylation, phosphorylation, sulfation, farnesylation, ubiquitination, and glycosylation, among others, and play a pivotal role in …

Protein chemical modification approaches can be roughly classified into three categories: 1) modifications via the reactivities of cAAs; 2) ribosomal-mediated incorporation of noncanonical …

2019年2月25日 · Recently developed methods for protein modification fall into two broad categories: those that can modify the natural protein template directly and those that require …

Protein modifications impart broad, far-reaching functional consequences on proteins. Some modifications are highly abundant, highly specific, or incredibly potent, whereas other …

2014年9月5日 · Chemical modification of proteins is an important tool for probing natural systems, creating therapeutic conjugates and generating novel protein constructs. Site-selective …

2023年7月19日 · Post-translational modification (PTM) of proteins refers to the chemical changes that occur after a protein has been produced. It can impact the structure, electrophilicity and …

2025年1月22日 · The Protein Modifications page describes many of the characterized modifications that are know to regulate protein structure and function

Minor modifications of proteins can be very important in regulating enzyme activity. Modest changes in structure can have a big impact on the conformation of the protein, which in turn …