2024年12月25日 · PRKCH (Protein Kinase C Eta) is a Protein Coding gene. Diseases associated with PRKCH include Stroke, Ischemic and Cortical Dysplasia, Complex, With Other Brain Malformations 13. Among its related pathways are Prolactin Signaling and ADORA2B mediated anti-inflammatory cytokines production.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.

2017年9月1日 · PRKCH is highly expressed in human and mouse hematopoietic stem cells and in acute myeloid leukemia (AML) stem cells. PRKCH deficiency compromises hematopoietic stem cell function. Elevated PRKCH expression correlates with RUNX1 and TP53 mutations in AML patients and predicts poor overall survival.

PRKCH is a prognostic marker in Kidney renal clear cell carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

2024年4月3日 · Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.

2007年2月23日 · By screening a human keratinocyte cDNA library using PRKCA fragments as probes, Bacher et al. (1991) isolated a cDNA encoding PRKCH, which they called PKCL. The predicted PRKCH protein contains 680 amino acids and …

2022年12月1日 · PRKCH, also known as PKC-eta, PKCη, belongs to the PKC family. It regulates cell proliferation, differentiation and death. In recent years, several studies have shown that PRKCH can inhibit cell senescence, resist apoptosis, and promote tumor cell proliferation in breast tumors, hepatocellular carcinoma and other tumors [7], [21], [22], [23].

We identified PRKCH (Protein Kinase C eta) as a gene that is highly expressed in both mouse and human HSCs, as well as in LSCs from independent cohorts of AML patients. Prkch deletion in mice resulted in impaired HSC function.

PRKCH - Explore an overview of PRKCH, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data.