The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation.

PAX-5, a transcription factor expressed throughout B-cell maturation, is detected in most B-cell neoplasms including those that lack expression of mature B-cell markers, such as classical Hodgkin lymphoma (cHL), B-lymphoblastic leukemia …

PAX-5 is the most sensitive and reliable immunohistochemical marker for B-cell malignancies (Dong et al., 2008). The nuclear positivity of PAX-5 makes it different from other pan B cells markers (CD20 and CD79a) which are membrane markers (Dong et al., 2008).

2024年12月25日 · PAX5 (Paired Box 5) is a Protein Coding gene. Diseases associated with PAX5 include Leukemia, Acute Lymphoblastic 3 and B-Lymphoblastic Leukemia/Lymphoma With T (7;9) (Q11.2;P13.2). Among its related pathways are Gene expression (Transcription) and Assembly of the pre-replicative complex.

Pax5, or B-cell-specific activator protein, is a nuclear protein in the paired-box containing (PAX) family of transcription factors involved in control of organ development and tissue differentiation.

2023年5月21日 · PAX5 (Paired box protein 5) is a type of protein called a transcription factor that plays an important role in the development and function of B cells, a type of white blood cells (WBCs) that are part of the body’s immune system. It is also known as BSAP (B-cell-specific activator protein) due to its specific expression in B cells.

2007年4月17日 · Conditional Pax5 inactivation in early and late B lymphocytes revealed an essential role for Pax5 in controlling the identity and function of B cells throughout B lymphopoiesis.