PTTG1 Gene - GeneCards | PTTG1 Protein | PTTG1 Antibody
2024年12月25日 · PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) is a Protein Coding gene. Diseases associated with PTTG1 include Pituitary Tumor and Prolactinoma. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Separation of Sister Chromatids.
PTTG1 - Wikipedia
PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase inhibitor PHA-848125. [13] References Further reading. This page was last edited on 10 April 2024, at 21:31 (UTC). Text is available under the Creative Commons Attribution-ShareAlike 4.0 ...
郭云蔚教授团队发现代谢重编程在肝癌过程中的关键作用 | 中山大 …
2023年6月20日 · 近日，中山大学附属第三医院郭云蔚教授团队等在Cancer Research（中科院一区，IF=13.312）上发表题为“PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression”的研究论著，发现在肝脏癌变及进展过程中，垂体肿瘤转化基因1（Pituitary tumor transforming gene 1 ...
PTTG1 - 药物、适应症、专利 - 智慧芽新药情报库
近日，中山大学附属第三医院郭云蔚教授团队等在Cancer Research上发表题为“PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression”的研究论文，发现在肝脏癌变及进展过程中，垂体肿瘤转化基因1（Pituitary tumor transforming gene 1, PTTG1）通过上调天冬酰胺 ...
垂体瘤转化基因 (PTTG1)可抵抗UV诱导的细胞凋亡作用
垂体瘤转化基因(pttg1)在很多肿瘤中呈高水平表达.越来越多的研究表明,pttg1与细胞增殖、细胞转化有关.但fitg1在凋亡中的作用仍不清楚.通过在细胞中下调和过表达pttg1,观察fitg1在uv照射诱导凋亡中的作用.结果发现,rnai-介导下调hela细胞vttg1表达可增加对uv诱导凋亡的 ...
Phosphorylated PTTG1 switches its subcellular distribution and
2023年7月3日 · PTTG1 positively regulates Wnt/β-catenin signaling by inhibiting the destruction complex assembly, promoting β-catenin stabilization and subsequent nuclear localization.
姐妹染色单体分离的 PTTG1 调节器，securin（PTTG1）基因 | MCE
姐妹染色单体分离的 PTTG1 调节器，securin： 编码的蛋白质是酵母 securin 蛋白的同系物，可防止 separins 促进姐妹染色单体分离。 它是一种后期促进复合物 (APC) 底物，与 separin 结合直至激活 APC。
PTTG1在肿瘤发病机制中作用的研究进展
2023年9月5日 · 摘要： 垂体肿瘤转化基因1(pttg1)是一种从垂体中分离出来的癌基因。它能结合并抑制分离酶从而影响姐妹染色单体分离导致染色体非整倍体,激活 dna 损伤反应途径诱导 p53依赖性衰老,还能反式激活一些癌基因进而促进细胞转化与裸鼠成瘤能力。
PTTG1IP Gene - PTTG1 Interacting Protein
2024年12月25日 · This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor.
The Role of RAC2 and PTTG1 in Cancer Biology - PubMed
2025年2月23日 · PTTG1, also known as human securin, regulates key processes such as cell cycle progression, apoptosis suppression, and EMT, promoting metastasis and enhancing cancer cell survival. This article aims to describe the molecular pathways involved in the proliferation, invasiveness, and drug response of cancer cells through RAC2 and PTTG1, aiming to ...