PTPN2 exerts synergistic anti-inflammatory effects in various inflammatory cells and regulates the developmental differentiation of immune cells. The diversity of PTPN2 effects in different types …

2025年2月12日 · PTPN2 (protein tyrosine phosphatase nonreceptor type 2) is an important member of the protein tyrosine phosphatase (PTP) family. It plays a crucial role in …

High PTPN2 Expression Was Independent Predictive Factors for Poor Outcomes in Pancreatic Adenocarcinoma Patients. Recently, PTPN2 has been identified as a potential target for …

2024年12月25日 · PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2) is a Protein Coding gene. Diseases associated with PTPN2 include Oligoarticular Juvenile Idiopathic …

2022年9月2日 · PTPN2 exerts synergistic anti-inflammatory effects in various inflammatory cells and regulates the developmental differentiation of immune cells. The diversity of PTPN2 …

2023年10月4日 · Here we present the discovery and characterization of ABBV-CLS-484 (AC484), a first-in-class, orally bioavailable, potent PTPN2 and PTPN1 active-site inhibitor. AC484 …

2024年5月29日 · Genetic deletion of PTPN2 in either tumor cells or host immune cells promotes the anti-tumor immunity. In addition, PTPN2 inhibitors, alone or in combination with anti-PD1 …

2017年7月19日 · In vivo CRISPR screening reveals that loss of Ptpn2 increases the response of tumour cells to immunotherapy and increases IFNγ signalling, suggesting that PTPN2 …

We show that, for the first time, protein-tyrosine phosphatase non-receptor type 2 (PTPN2) regulates the KRAS plasma membrane association and plays an important role in KRAS …

Protein tyrosine phosphatase non-receptor type 2 and protein tyrosine phosphatase non-receptor type 1 (PTPN2/N1) are closely related members of the protein tyrosine phosphatase family …