PIM1 - Wikipedia
Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by the Moloney murine leukemia virus. [8] .
PIM1 Gene - GeneCards | PIM1 Protein | PIM1 Antibody
2024年12月25日 · PIM1 (Pim-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PIM1 include Myeloma, Multiple and Myeloproliferative Neoplasm. Among its related pathways are FLT3 signaling in …
Pim1 promotes IFN-β production by interacting with IRF3 - Nature
2022年11月29日 · Here, we show for the first time that Pim1 plays an essential role in the production of interferon (IFN)-β by macrophages after their Toll-like receptor (TLR) pathway is activated by...
PIM1 kinase and its diverse substrate in solid tumors - PMC
PIM1 kinase is often overexpressed in solid and hematopoietic malignancies, promoting cell survival, proliferation, migration, and senescence by activating key genes. In vitro and in vivo studies have established the oncogenic potential of PIM1 kinases.
PIM1 kinase regulates cell death, tumor growth and ... - Nature
2016年10月24日 · In triple-negative breast cancer, the kinase PIM1, which is highly expressed, functions through the transcription factor c-MYC to promote tumor cell survival and growth.
Pim1 Kinase Inhibitors Exert Anti-Cancer Activity Against ...
The proviral integration site for moloney murine leukemia virus 1 (Pim1) is a serine/threonine kinase and able to promote cell proliferation, survival and drug resistance. Overexpression of Pim1 has been observed in many cancer types and is ...
PIM1 kinase and its diverse substrate in solid tumors
2024年11月1日 · PIM1 kinase is often overexpressed in solid and hematopoietic malignancies, promoting cell survival, proliferation, migration, and senescence by activating key genes. In vitro and in vivo studies have established the oncogenic potential of PIM1 kinases.