2024年12月25日 · NUAK1 (NUAK Family Kinase 1) is a Protein Coding gene. Diseases associated with NUAK1 include Omphalocele and Endometrial Squamous Cell Carcinoma. Among its related pathways are Gene expression (Transcription) and Regulation of TP53 Activity.

High NUAK1 expression correlates with poor prognosis and involved in human nonsmall cell lung cancer cells migration and invasion. ARK5 can promote glioma cell invasion by regulating cytoskeleton rearrangement and matrix metalloproteinase activation.

In this review, we discuss the interplay between TGF-β signaling and the AMP-activated protein kinase (AMPK)-related NUAK kinase family. We highlight the function and regulation of these kinases with focus on the pivotal role NUAK1 and NUAK2 play in regulating TGF-β signaling.

2024年3月21日 · Here, the authors uncovered that the AMPK-related kinase NUAK1 controls axonal mitochondrial metabolism through the regulation of the mitochondrial microprotein BRAWNIN.

2020年9月1日 · NUAK1 (also known as ARK5) is one of 12 kinases from the AMPK subfamily and is critical for maintaining metabolic homeostasis by regulating the mitochondrial respiratory chain complex and the...

NUAK1 and NUAK2 belong to a family of kinases related to the catalytic α-subunits of the AMP-activated protein kinase (AMPK) complexes. Despite canonical activation by the tumour suppressor kinase LKB1, both NUAKs exhibit a spectrum of activities that favour tumour development and progression.

2022年3月23日 · Here, we describe NUAK family kinase 1 (NUAK1) as a TGF-β-inducible profibrotic kinase that is up-regulated in multiple fibrotic organs in mice and humans. Mechanistically, we show that TGF-β induces a rapid increase in NUAK1 in fibroblasts.

Our recent findings demonstrate an ability of NUAK1 to induce premature senescence in normal human cells whereas others, mainly the team of H. Esumi, have demonstrated a pro tumoral effect of NUAK1 through promoting cell growth and invasion [13, 14, 15].

Enables p53 binding activity and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of cellular senescence; and regulation of myosin-light-chain-phosphatase activity.

2013年9月10日 · This review contains a brief discussion of the NUAK family including the specific characteristics of NUAK1 and NUAK2. Keywords: AMP-activated protein kinase (AMPK); AMPK-related kinase; ARK5; LKB1; NUAK family; sucrose-non-fermenting protein kinase (SNF1)/AMPK-related kinase (SNARK).