Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer, regardless of where they …

The identification of cancer patients harboring NTRK gene fusions is constantly growing, especially with the advent of NTRK inhibitors. This has promisingly provided a rationale for …

In this Review, we discuss the biology of NTRK fusions, strategies to target these drivers in the treatment-naive and acquired-resistance disease settings, and the unique safety profile of …

2021年9月16日 · Neurotrophic tropomyosin-receptor kinase (NTRK) genes encode a family of transmembrane-receptor tyrosine kinases that play an important role in neural development. …

NTRK fusions are clinically actionable: first-generation TRK tyrosine kinase inhibitors (larotrectinib or entrectinib) result in histology-agnostic responses in both adult and paediatric patients with …

2021年7月20日 · Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are rare oncogenic drivers in solid tumours. This study aimed to interrogate a large real-world database …

NTRK fusions are bona fide oncogenic lung cancer drivers. NTRK fusion-positive lung cancers share a similar clinical profile with many other fusion-positive lung cancers. The approved first …

2025年1月22日 · NTRK is an important biomarker that can impact lung what treatment options. The videos above were produced in 2020. For the latest treatment options, speak with your …

The NTRKers is a global, non-profit patient group, founded by patients and loved ones living with NTRK gene fusion cancer, and supported by leading clinical experts. Changes to the NTRK …

NTRK gene fusions are one such targetable aberration. The neurotrophin receptor tyrosine kinase (NTRK) family is made up of 3 genes crucial to nervous system development and physiology. …