Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. [5] [6] [7]

2024年12月25日 · NRG4 (Neuregulin 4) is a Protein Coding gene. Diseases associated with NRG4 include Diabetes Mellitus and Lysosomal Storage Disease. Among its related pathways are Signaling by ERBB2 KD Mutants and Constitutive Signaling by Aberrant PI3K in Cancer.

2014年11月17日 · Here we show that neuregulin 4 (Nrg4), a member of the epidermal growth factor (EGF) family of extracellular ligands, is highly expressed in adipose tissues, enriched in brown fat and...

2024年3月1日 · The variants of Nrg4 gene and the sequence alignment of Nrg4 proteins among species. (A) The human Nrg4 gene encodes five different isoforms, namely A1, A2, B1, B2, and B3.

Nrg4 was identified as the fourth Nrg in 1999 (Harari et al., 1999) and functions favorably via ErbB4. Nrg4 exerts a major role in glycolipid metabolism and energy homeostasis as an adipokine enriched in brown adipose tissue (BAT). (Gavaldà-Navarro et al., 2022).

In this study, we found that NRG4, a novel adipokine, is obviously decreased in adipocyte tissues and serums during aging. Moreover, delivered recombinant NRG4 protein (rNRG4) into aged mice can ameliorate age-associated insulin resistance, …

Neuregulin 4 (Nrg4), an adipose tissue-enriched endocrine factor, participates in adipocyte-to-hepatocyte communication, eliciting beneficial metabolic effects in nonalcoholic fatty liver disease (NAFLD). We evaluate the physiological roles of NRG4 in …

Neuregulin 4 (Nrg4), a novel brown fat-enriched hormone, plays a key role in the modulation of glucose and lipid metabolism and energy balance. Recent data have demonstrated that the expression of Nrg4 is substantially down-regulated in mouse and human obesity, making its regulatory aspect intriguin …

2025年2月8日 · describes a novel splice variant of the NRG4 gene, NRG4A2, which encodes a C-terminal region containing a predicted type I PDZ-binding peptide; NRG4 was positive in almost all breast cancers studied. NRG4 overexpression is associated with advanced-stage prostate cancer; Neuregulin-4 expression is downregulated during urinary bladder cancer ...

Neuregulins, with the exception of neuregulin-4 (NRG4), have been shown to be extensively involved in many aspects of neural development and function and are implicated in several neurological disorders, including schizophrenia, depression and bipolar disorder.