Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. [5] [6] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered.

2024年12月25日 · MST1R (Macrophage Stimulating 1 Receptor) is a Protein Coding gene. Diseases associated with MST1R include Nasopharyngeal Carcinoma 3 and Papillary Adenocarcinoma. Among its related pathways are GPCR Pathway and ERK Signaling.

2023年11月6日 · Recepteur d’origine nantais (RON, MST1R) is a single-span transmembrane receptor tyrosine kinase (RTK) aberrantly expressed in numerous cancers, including various solid tumors.

MST1R (RON) expression is a novel prognostic biomarker for metastatic progression in breast cancer patients. OPN promotes the aggressiveness of non-small-cell lung cancer cells through the activation of the RON tyrosine kinase.

2023年5月1日 · MST1R expression was positively correlated with TGF-β. Our results demonstrate that MST1R has the potential as a new target antigen for treating breast cancer, lung adenocarcinoma, and bladder cancer and may be used as …

Macrophage stimulating 1 receptor (MST1R) is a C-MET proto-oncogene family receptor tyrosine kinase. Promoter methylation patterns determine transcription of MST1R variants as hypermethylation of a region upstream of transcription start site (TSS) ...

2022年4月18日 · The MST1R/RON receptor tyrosine kinase is a homologue of the more well-known MET receptor. Like MET, RON orchestrates cell signaling pathways that promote oncogenesis and enable cancer cell survival; however, it …

The MST1R (RON) kinase is overexpressed in >80% of human pancreatic cancers, but its role in pancreatic carcinogenesis is unknown. In this study, we examined the relevance of Mst1r kinase to Kras driven pancreatic carcinogenesis using genetically engineered mouse models.

Macrophage stimulating 1 receptor (MST1R) is a gene that encodes a protein that functions as a tyrosine kinase receptor for macrophage-stimulating protein. Apart from functioning as a receptor, the protein may also be involved in host defense.

2019年4月9日 · In the setting of mutant Kras, Mst1r overexpression increased acinar-ductal metaplasia (ADM), accelerated the progression of pancreatic intraepithelial neoplasia (PanIN), and resulted in the...