2024年12月25日 · MPV17L (MPV17 Mitochondrial Inner Membrane Protein Like) is a Protein Coding gene. Diseases associated with MPV17L include Autosomal Dominant Nonsyndromic Deafness 77 and Chromosome 16P13.3 Duplication Syndrome. Gene Ontology (GO) annotations related to this gene include signaling receptor binding. An …

2008年9月16日 · Mpv17l is a transmembrane protein previously implicated in peroxisomal reactive oxygen species metabolism and a close homolog of the inner mitochondrial membrane protein Mpv17. Here we demonstrate a previously undescribed direct interaction between Mpv17l and HtrA2 in mitochondria.

2008年9月16日 · Mpv17l is a transmembrane protein previously implicated in peroxisomal reactive oxygen species metabolism and a close homolog of the inner mitochondrial membrane protein Mpv17. Here we demonstrate a previously undescribed direct interaction between Mpv17l and HtrA2 in mitochondria.

Gene ID: 255027, updated on 8-Feb-2025. Involved in negative regulation of hydrogen peroxide biosynthetic process; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; and reactive oxygen species metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Feb 2025]

MPV17L, a member of the MPV17 (137960)/PMP22 (601097) protein family, is involved in cell protection by contributing to mitochondrial DNA repair (Iida et al., 2015). By searching genomic sequence databases for sequences similar to that of MPV17, followed by RACE, Iida et al. (2006) identified the MPV17L gene, which they called MLP.

2025年2月8日 · Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice. Deficiency of M-LP/Mpv17L leads to development of beta-cell hyperplasia and improved glucose tolerance via …

These results suggest that suppression of M-LP/Mpv17L expression or activity can alleviate diabetes-associated conditions such as hyperglycemia, and that M-LP/Mpv17L might be a potential target for treatment of diabetes.

Mpv17l is a transmembrane protein previously implicated in peroxisomal reactive oxygen species metabolism and a close homolog of the inner mitochondrial membrane protein Mpv17. Here we demonstrate a previously undescribed direct interaction between Mpv17l and HtrA2 in …

2022年3月1日 · M-LP/Mpv17L is a protein that was initially identified during screening of age-dependently expressed genes in mice. We have recently demonstrated that M-LP/Mpv17L-knockout (M-LP/Mpv17L-KO) in human hepatoma cells leads to a reduction of cellular cyclic nucleotide phosphodiesterase (PDE) activity, an …

2009年10月13日 · The Mpv17l protein has two isoforms, M-LP L and M-LP S, which both regulate the production of reactive oxygen species (ROS) and protect against mitochondrial oxidative stress and apoptosis. M-LP L is ubiquitously expressed, while M-LP S is expressed mostly in the kidney of aged animals.